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The AIDS and Cancer Specimen Resource (ACSR) was established by the National Cancer Institute in 1994 and serves as "a biorepository for HIV-infected human biospecimens from a wide spectrum of HIV-related or associated diseases, including cancer, and from appropriate HIV-negative controls." The ACSR acquires, stores, and equitably distributes these clinical samples to the scientific research community; the ACSR database contains more than 300,000 biospecimens with associated clinical data. The website offers information about the types of specimens available and the procedure for requesting samples, including application forms. A bibliography of publications from researchers using this resource is provided.

The resources on the AIDS Community Research Initiative of America (ACRIA) website reflect an advocacy/activism approach and are primarily aimed at patients, non-physician providers, and service organizations. ACRIA's HIV Health Literacy Program publications and information on the organization's HIV training programs and workshops are provided. The site offers resources from ACRIA's unique Center on HIV and Aging, which seeks to better understand HIV/AIDS in older adults. Clinical trial information includes lists of current community-based trials; recent trial results; and TrialSearch, a searchable national database that allows the user to search for HIV/AIDS trials by geographic location, condition, and treatment, as well as limit results according to eligibility criteria such as CD4 count, viral load, and age.

This site serves as a central repository for HIV/AIDS training materials developed within the AIDS Education and Training Centers (AETC) network and includes resources for both trainers and clinicians. Trainer resources include curricula, slide decks, videos, links to online study, and resources on training methods and program development. For clinicians, the site offers links to clinical guidelines and manuals, support tools (charts/tables, PDA tools, patient handouts, pocket guides), and reference materials.

AIDS Vaccine Advocacy Coalition (AVAC) is an international nonprofit organization devoted to the "ethical development and eventual global delivery of AIDS vaccines and other new HIV prevention options." Although the AVAC website largely reflects an advocacy audience and approach, it does offer several unique research-oriented resources and tools. Research summaries, information on ongoing and completed clinical trials, and factsheets are provided for a variety of HIV prevention topics (including vaccines, pre-exposure prophylaxis, microbicides, and male circumcision). Other useful features include an interactive map, which allows users to click on countries around the world to identify current HIV prevention trials, and a timeline of expected results from prevention trials. Another helpful research tool is the Clinical Trial Site Capacity Database, which provides "a comprehensive inventory of microbicide [and other prevention strategy] clinical trial sites' clinical, laboratory, and staffing capacity" to maximize efficient site use. Additional site content includes AVAC reports, newsletters, educational materials, and project news.

The AIDS.gov website provides HIV/AIDS information from the US government and is oriented towards consumers, health departments, and service organizations. Features include links to federal resources and funding for AIDS testing, prevention, treatment, awareness, and medical research, as well as information on HIV/AIDS policies and issues. The "HIV/AIDS Basics" section offers consumer-oriented information on the disease state and living with AIDS. The site also provides guidance on using new media (blogs, podcasts, RSS feeds, etc) to disseminate HIV/AIDS information.

This site offers information on the American Foundation for AIDS Research (amFAR) broad range of HIV/AIDS initiatives. Global projects, such as TREAT Asia (Therapeutics Research, Education, and AIDS Training in Asia) and the MSM (men who have sex with men) Initiative, are described. Community resources include a variety of downloadable publications, videos, and other educational tools. The "In the Lab" section highlights amfAR's research program, provides information on research grants and application procedures, and lists publications by grantees and fellows. amfAR's public policy and advocacy activities are detailed in "On the Hill."

The Body website is a consumer-oriented website which provides a good introduction to clinical studies, medical research, and clinical trial participation in HIV/AIDS research. This webpage links to various clinical trial databases and allows the user to browse trials by category (pediatric, acute/early infection, etc). Links to articles about HIV/AIDS Clinical Trials are available on the website.

This webpage provides a list of cell lines related to HIV/AIDS vaccine research at CHAVI (Center for HIV-AIDS Vaccine Immunology). Contact information for each cell line is included.

This webpage provides a list of HIV-related immunogens available to vaccine researchers. Contact information for each immunogen is provided.

This webpage provides a list of mouse monoclonal antibodies available to HIV vaccine researchers. Contact information for each antibody is provided.

This site primarily focuses on HIV/AIDS epidemiology, surveillance, and prevention. This is an excellent source for US HIV/AIDS statistics; surveillance reports, factsheets, and slide sets for various demographic groups are available. The site offers guidance and resources on HIV prevention and control in healthcare settings. Other features include podcasts, brochures, and publications focused on disease awareness, testing, and prevention. Several analysis softwares and the AIDS Public Information Data Set are available for download.

The CFAR Network of Integrated Clinical Systems (CNICS) is an electronic medical records network that integrates clinical data from HIV patients receiving care at CFAR sites and tracks the outcomes of clinical practice decisions. Publicly accessible information includes a bibliography of CNICS publications, a list of CNICS data elements, and cohort demographics. To access CNICS data or specimens, a Concept Proposal Application must be submitted and approved.

The Cochrane HIV/AIDS group prepares systematic literature reviews of HIV prevention and treatment interventions to support evidence-based medicine. Available reviews fall under the categories of Behavior, Social and Policy Prevention; Biomedical Prevention; Therapeutics, Prognostics and Diagnostics; and Health Services and Care. Abstracts and lay summaries of the reviews are offered on this website; links are provided to the full-text reviews. Video, audio, and slide presentations for past Cochrane Colloquia are also available.

The Emory Vaccine Center was established in 1996 and represents one of the largest academic vaccine centers in the world. Areas of research at the Emory Vaccine Center include HIV/AIDS; malaria; basic immunology and virology; cancer; and bio-defense pathogens.

The Forum for Collaborative HIV Research is a private/public partnership with a mission to facilitate HIV/AIDS research by bringing together all stakeholders, including government agencies, the pharmaceutical industry, researchers, clinicians, and patient advocates. The website provides overviews of Forum treatment and prevention projects; information regarding HIV cohorts and datasets is also available. Reports and slide presentations from Forum meetings, as well as journal articles pertaining to Forum projects, are provided in pdf format.

Global Campaign for Microbicides (GCM) is "a diverse network of advocates and nongovernmental organizations (NGOs) working to expand HIV prevention options and encourage ethical research that involves civil society." The GCM website offers good general information about microbicides and a wealth of information about microbicide clinical trial results. Numerous resources, including factsheets, slide presentations, and in-depth reports, are provided regarding the ethics of HIV microbicide and other prevention trials. Other available materials include GCM newsletters, conference reports, executive summaries, and an excellent microbicides e-learning course (free, but requires registration).

The U.S. Department of Health and Human Services Health Resources and Services Administration (HRSA) provides HIV/AIDS care through the Ryan White Program to people with insufficient health care coverage. The HRSA website contains information about Ryan White Program services, annual reports, funding, and state profiles. Resources for those involved in providing HIV care are available, including links to clinical care guidelines, quality performance measures, and training materials. The "Manage Your Ryan White Grant" section of the website offers assistance and resources (including CAREWare software) to grantees in managing grants and meeting reporting requirements, as well as guidance on the application process.

Produced and maintained by the New York State Department of Health AIDS Institute in collaboration with Johns Hopkins University Division of Infectious Diseases, the site offers a variety of tools for clinicians to support quality care for HIV/AIDS. An extensive set of clinical guidelines is available, covering various patient populations and related co-morbidities. Quality initiatives and best practices for HIV care from New York state are provided. The site offers a variety of clinical education tools, including slide presentations and grand round videos on HIV-related topics. Other resources include quick reference cards, patient materials, and mental health and substance abuse screening tools.

From Flying Publisher, HIV Medicine 2007 is an online medical textbook that provides a comprehensive overview of HIV infection and treatment. The nearly 800-page textbook covers a wide range of topics, including acute HIV infection; antiretroviral medications and their side effects; AIDS-related malignancies; and various comorbidities, including cardiac, pulmonary, and neuromuscular diseases. Chapters on special topics such as traveling with HIV, sexual dysfunction, and "HIV and Wish for Parenthood" are included. The textbook also provides helpful drug profile and drug-drug interaction sections. The textbook is also available in Vietnamese, Portuguese, Russian, Spanish, and Persian.

Provided by the Los Alamos National Laboratory (LANL) and funded through an NIAID grant, the HIV Molecular Immunology Database "is an annotated, searchable collection of HIV-1 cytotoxic and helper T-cell epitopes and antibody binding sites." The database contains 3 search options: CTL/CD8+, T helper/CD4+, and antibody. Epitope maps, epitope tables, and HLA Typing and Epitope Mapping Data Sets are available. A variety of immunology tools are also provided, and the annual HIV Immunology Database Compendia can be downloaded in pdf format.

Provided by the Los Alamos National Laboratory (LANL) and funded through an NIAID grant, the HIV Sequence Database has collected all HIV and SIV sequences since 1987; sequences are obtained from GenBank, EMBL, or DDBJ. The search interface allows users to retrieve HIV and SIV sequences, which can then be aligned and used to build trees. HIV premade alignments are also available. The Geography Search Interface allows for the retrieval of HIV sequences based on geographical distribution; an interactive map is used for this feature. Various online tools are available to use with the database and cover functions such as analysis and quality control, alignment and sequence manipulation, phylogenetics, database search interfaces, immunology, and format and display. Tutorials and an FAQ section provide help in using the site and its tools. The annual HIV Sequence Compendium is available for download in pdf format.

The HIV Vaccine Trials Network (HVTN) is an international scientific collaboration on HIV vaccine discovery and development. The site's overview of HVTN science provides general information on HIV vaccine strategies and possible outcomes. HVTN study sites and open trials are listed, but more detailed study information and protocols are not included on the website. A variety of community resources are available, including sections focusing on special populations (African Americans, Native Americans and Alaskans, etc). HVTN actively pursues new research ideas and investigators through award postings and research proposal solicitations. More information is available to HVTN members through the HVTN Portal, which requires a login password.

HIV Web Study is an excellent free online learning system for healthcare workers provided by the Northwest AETC and the University of Washington. This educational resource is offered as a series of case-based modules. Users are presented with a clinical situation and a multiple choice question; the accompanying discussion section, explanatory figures, and reference list support the correct answer for each case. Module topics include HIV dermatologic and oral manifestations, opportunistic infections, antiretroviral treatments, postexposure prophylaxis, and special populations. Several interactive tutorials are also available on the website. Free CME credit is available for completion of each module.

Pharmacogenomics Databank allows users to search a comprehensive database for information relevant to HIV management by gene, enzyme, or toxicity type. A complete HIV pharmacogenomics reference table is also available in PDF format. Other resources include brief summaries of current HIV pharmacogenomics literature and reports on relevant conference presentations.